Abstract #2592

Open-source Multi-Spin Echo T2 Mapping Optimized for Knee Articular Cartilage

Tiago T. Fernandes¹, Andreia S. Gaspar¹, Jochen Schmidt^2,3, Ana Alfaiate¹, Patrick Scheibe², José M. Coelho^4,5, Vasco Mascarenhas⁶, Sairam Geethanath^7,8, and Rita G. Nunes¹

¹Institute for Systems and Robotics - Instituto Superior Técnico – Universidade de Lisboa, Lisboa, Portugal, ²Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, Leipzig, Germany, ³International Max Planck Research School on Neuroscience of Communication: Function, Structure and Plasticity, Leipzig, Germany, Leipzig, Germany, ⁴Centro Hospitalar Universitário de Santo António, Unidade Local de Saúde de Santo António, Clínica de Imagiologia Diagnóstica e de Intervenção, Porto, Portugal, Porto, Portugal, ⁵Radiology Department, Escola Superior de Saúde / Instituto Politecnico do Porto, Porto, Portugal, Porto, Portugal, ⁶Hospital da Luz Learning Health, Luz Saúde, Lisboa, Portugal, Lisboa, Portugal, ⁷Laboratory for Accessible Magnetic Resonance, Division of Cancer Imaging Research, Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, USA, Baltimore, MD, United States, ⁸Accessible Magnetic Resonance Laboratory, Biomedical Imaging and Engineering Institute, Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, New York, NY, United States

Synopsis

Keywords: Pulse Sequence Design, Acquisition Methods, Accessible MRI, Open-Source MRI, Quantitative MRI, T2 Map, Optimization

Motivation: Osteoarthritis affects one-fourth of the world’s population. Interest in applying quantitative MRI (qMRI) for early detection and follow-up of this disease has grown but ensuring reproducibility of the measurements across vendors remains necessary.

Goal(s): To design and optimize an Open-Source Multi-Spin-Echo (MSE) pulse sequence for standardizing T2 Knee Articular Cartilage (KAC) mapping.

Approach: Cramer-Rao Lower Bound (CRLB) was used to maximize sensitivity to KAC T2 values. Repeatability tests were carried out in the NIST phantom and a pilot in vivo scan was performed.

Results: Phantom results support improved specificity and demonstrate increased reproducibility over time. Pilot in vivo KAC data proves feasibility.

Impact: Multi-Spin Echo sequences for T2 mapping knee articular cartilage were made available as open-source vendor-agnostic tools to enable future quantitative MRI standardization studies. NIST phantom evaluation tests suggest improved precision with the proposed optimization. Pilot in vivo data demonstrates feasibility.

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