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Abstract #2598

Does it matter which subspectra are modelled in GABA-edited MRS?

Zahra Shams1,2, Saipavitra Murali-Manohar1,2, Helge J. Zöllner1,2, Georg Oeltzschner1,2, and Richard A.E. Edden1,2
1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Keywords: Signal Modeling, Spectroscopy

Motivation: Modeling of GABA-edited data is commonly performed on the difference spectrum. However, linear-combination modeling can also be performed on each subspectrum, and simultaneous modeling of DIFF and SUM spectra (or the ON and the OFF) has been suggested to improve accuracy.

Goal(s): To compare the accuracy of simultaneous against single-spectrum modeling, and to compare ON&OFF to DIFF& SUM modeling.

Approach: 100 time-domain spectra containing GABA and Cr were synthesized and modeled with six approaches.

Results: Simultaneous modeling (ON&OFF or DIFF&SUM) out-performed DIFF-only, even where the SUM spectrum could not be modeled in isolation. The ON&OFF model gave equivalent outcomes to DIFF&SUM.

Impact: New, more flexible MRS modeling software allows modeling of multiple sub-spectra of edited experiments, and it is important to appreciate the implications of choices of modeling approach.

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