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Abstract #2602

Rapid, High-resolution and Distortion-free R2* Mapping of Fetal Brain using Multi-echo Radial FLASH and Model-based Reconstruction

Xiaoqing Wang1, Hongli Fan2, Serge Vasylechko1, Onur Afacan1, Edward Yang1, Martin Uecker3, Simon K. Warfield1, and Ali Gholipour1,4
1Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 2Siemens Medical Solutions, Boston, MA, United States, 3Institute of Biomedical Imaging, Graz University of Technology, Graz, Austria, 4Department of Radiological Sciences, University of California Irvine, Irvine, CA, United States

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging, Fetal imaging; R2* mapping; radial FLASH; model-based reconstruction

Motivation: Quantitative R2*mapping of fetal brain is of great interest. While existing EPI-based approaches are efficient, they may suffer from low spatial resolution and field distortion artifacts.

Goal(s): To develop a rapid, high-resolution and distortion-free quantitative R2* mapping approach for fetal brain.

Approach: A 2D radial multi-echo FLASH sequence with blip gradients is adapted for data acquisition. A nonlinear model-based reconstruction is developed to estimate motion-robust quantitative fetal brain maps directly from k-space.

Results: Validated on simulations, NIST phantoms, and fetuses, the proposed technique achieves distortion-free quantitative R2* maps at a nominal spatial resolution of 1.1 x 1.1 x 3 mm³ within 2 seconds.

Impact: Our technique enables high-resolution, distortion-free R2* mapping of the fetal brain using radial multi-echo acquisition and model-based reconstruction. This approach overcomes the low resolution and field distortion artifacts common in EPI-based methods.

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