Keywords: Quantitative Imaging, Quantitative Imaging, Fetal imaging; R2* mapping; radial FLASH; model-based reconstruction
Motivation: Quantitative R2*mapping of fetal brain is of great interest. While existing EPI-based approaches are efficient, they may suffer from low spatial resolution and field distortion artifacts.
Goal(s): To develop a rapid, high-resolution and distortion-free quantitative R2* mapping approach for fetal brain.
Approach: A 2D radial multi-echo FLASH sequence with blip gradients is adapted for data acquisition. A nonlinear model-based reconstruction is developed to estimate motion-robust quantitative fetal brain maps directly from k-space.
Results: Validated on simulations, NIST phantoms, and fetuses, the proposed technique achieves distortion-free quantitative R2* maps at a nominal spatial resolution of 1.1 x 1.1 x 3 mm³ within 2 seconds.
Impact: Our technique enables high-resolution, distortion-free R2* mapping of the fetal brain using radial multi-echo acquisition and model-based reconstruction. This approach overcomes the low resolution and field distortion artifacts common in EPI-based methods.
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