Abstract #2616

High resolution synthetic late gadolinium enhancement based on accelerated post-contrast T1 mapping

Juan Gao¹, Yiwen Gong², Zhuo Chen¹, Haiyang Chen¹, Yixin Emu¹, Xiao-Yong Zhang^3,4, Zhongjie Zhou², Wei Jin², Sha Hua², and Chenxi Hu¹

¹National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Department of Cardiovascular Medicine, Heart Failure Center, Ruijin Hospital Lu Wan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Faculty of Medical Imaging Technology, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Synopsis

Keywords: Quantitative Imaging, Cardiomyopathy, LGE, high-resolution, acceleration, T1 mapping, sythetic

Motivation: Late gadolinium enhancement (LGE) cardiac MRI is the non-invasive gold standard for detecting myocardial scars and fibrosis. However, it has limitations, including incomplete myocardial nulling and sensitivity to motion.

Goal(s): To develop a high-resolution synthetic LGE method based on accelerated post-contrast T1 mapping to address these limitations.

Approach: We compared the proposed method with regular-resolution synthetic LGE and conventional LGE in a cohort of 50 patients with suspected cardiomyopathy.

Results: The proposed method reduces artifacts, enhances myocardial nulling, improves overall image quality, and achieves an accuracy for assessing myocardial scar comparable to that of conventional LGE.

Impact: The proposed method can achieve a similar accuracy in assessing myocardial scar relative to conventional LGE, while offering superior image quality, improved myocardial nulling, and an ability to simultaneously detect focal and diffuse fibrosis.

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