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Abstract #2624

Bipolar Flip Angle Modulated Chemical Shift Encoded Imaging Enabled with Gradient Impulse Response Function

James Hao Wang1,2, Jiayi Tang1,2, Daiki Tamada2, Ty Cashen3, Ali Pirasteh2, Diego Hernando1,2, and Alan McMillan1,2
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3GE HealthCare, Madison, WI, United States

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging, Liver, GIRF

Motivation: Unipolar FAM enables motion robust CSE imaging but would benefit from shorter echo and scan times to account for PDFF quantification with a high R2*.

Goal(s): We aim to develop a CSE sequence with shorter TE and scan time with robust PDFF quantification within patients.

Approach: Gradient impulse response function (GIRF) was used to account for gradient-related phase errors that complicate PDFF measurements in bipolar 2D-FAM.

Results: Bipolar 2D-CSE with GIRF correction enabled accurate PDFF measurement with similar results to 3D-CSE and better performance than unipolar 2D-CSE at high R2*.

Impact: This study explores the application of GIRF to enable bipolar 2D-FAM for PDFF quantification. Results are comparable to conventional 3D-CSE and unipolar 2D-FAM, but yield scan time reduction, increase in R2* dynamic range, and shorter ∆TE.

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Keywords