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Abstract #2664

Phase-Based R2 Mapping for Single Breath-Hold Whole-Liver Iron Quantification : Clinical Validation

Daiki Tamada1, Ruvini Navaratna1, Jayse Merle Weaver1, Diego Hernando1,2, and Scott B Reeder1,2,3,4,5
1Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 3Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 4Medicine, University of Wisconsin-Madison, Madison, WI, United States, 5Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Hepatobiliary, Liver, Iron overload

Motivation: Liver iron overload can cause serious complications; accurate assessment is essential. Current R2 mapping techniques are limited by long scan times and fat-induced bias.

Goal(s): To validate a rapid phase-based (PB) R2 mapping method for whole-liver iron quantification by comparing it with conventional methods, and to understand fat bias through simulations.

Approach: PB-R2 mapping using RF phase-modulated 3D GRE imaging was tested in patients with iron overload at 1.5T and 3.0T MRI.

Results: PB-R2 mapping showed good agreement with reference methods over a wide range of iron concentrations and excellent repeatability.

Impact: PB-R2 mapping enables rapid, accurate whole-liver iron quantification within a single breath-hold, enhancing clinical efficiency and patient comfort. It may improve iron overload assessment and inspire further research to address fat bias in R2 mapping.

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