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Abstract #2668

Deuterium MRS for in vivo measurement of lipogenesis in the liver

Ayhan Gursan1, Robin A. de Graaf2,3, Monique A. Thomas2, Jeanine J. Prompers1,4, and Henk M. De Feyter2,3
1Center for Image Sciences, University Medical Center, Utrecht, Netherlands, 2Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 3Department of Biomedical Engineering, Yale University, New Haven, CT, United States, 4Departments of Human Biology and Imaging, Maastricht University Medical Centre+, Maastricht, Netherlands

Synopsis

Keywords: Liver, Metabolism, lipogenesis

Motivation: The need for a technique to measure de novo lipid synthesis (DNL) directly in the liver instead of relying on a plasma-based assay.

Goal(s): Acquire proof-of-principle data in liver to show feasibility in vivo, and provide initial validation of the DNL estimate.

Approach: Preclinical study in vivo in rats, with a dietary challenge known to increase DNL. Compare the in vivo-based estimates of liver DNL with calculations of DNL based on 1H and 2H NMR data acquired in extracted lipids from excised liver tissue.

Results: The 2H lipid level measured in vivo correlated with the ex vivo estimates of hepatic DNL.

Impact: The initial observations in vivo in a rat model provide a basis for this approach to be translated and develop noninvasive, quantitative measurements of hepatic DNL in humans.

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