Keywords: Digestive, Tumors, Extranodal extension
Motivation: MRI could detect extranodal extension (ENE) in rectal cancer, a feature of metastatic lymph nodes, but its prognostic implication has not been fully demonstrated.
Goal(s): To explore the impact of ENE status and its changes before and after neoadjuvant therapy (NAT) on the prognosis of patients with locally advanced rectal cancer.
Approach: Potential risk factors were evaluated on pre- and post-NAT MRI in a retrospective cohort and their association with prognosis was determined.
Results: ENE status was the only independent risk factor on both pre- and post-NAT MRI, and changes in ENE status allowed stratification of patients with different prognoses.
Impact: Extranodal extension status and its changes on MRI have strong prognostic implications in locally advanced rectal cancer patients, which may become a new indicator for the selection of appropriate treatment regimens in the future.
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