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Abstract #2682

Tumor Microstructural Measurement at Time-Dependent Diffusion MRI Mapping for Predicting Lymphovascular Invasion in Rectal Cancer

Fulin Lu1, Meining Chen 2, Ran Wu1, Kuide Li1, Zonghui Liao1, and Hang Li1
1Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China, 2MR Research Collaboration Siemens Healthineers, Chengdu, China

Synopsis

Keywords: Cancer, Microstructure, Rectal cancer; Oscillating gradient spin-echo; Pulsed gradient spin-echo

Motivation: Early prediction of lymphovascular invasion (LVI) in rectal cancer is crucial for treatment planning. Current imaging methods lack sufficient ability for detecting LVI-related microstructural changes, warranting advanced MRI biomarkers for improved assessment.

Goal(s): This study evaluates the correlation between microstructural parameters obtained from time-dependent diffusion MRI (td-dMRI), ADC measurements and LVI to identify optimal predictive indicators.

Approach: Eighty-four patients rectal cancer underwent td-dMRI using OGSE and PGSE sequences. Four microstructural parameters and eight ADC measurements were assessed.

Results: Combination of intracellular volume fraction (ICVF), cellularity, and MRI-reported extramural venous invasion (EMVI) achieved the highest predictive performance for LVI.

Impact: The intracellular volume fraction (ICVF) from td-dMRI shows promise as a biomarker for LVI in rectal cancer. Combining ICVF and cellularity with MRI-reported EMVI enhances predictive performance, supporting clinicians in identifying high-risk patients for targeted treatment strategies.

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