Keywords: Cancer, Microstructure, Rectal cancer; Oscillating gradient spin-echo; Pulsed gradient spin-echo
Motivation: Early prediction of lymphovascular invasion (LVI) in rectal cancer is crucial for treatment planning. Current imaging methods lack sufficient ability for detecting LVI-related microstructural changes, warranting advanced MRI biomarkers for improved assessment.
Goal(s): This study evaluates the correlation between microstructural parameters obtained from time-dependent diffusion MRI (td-dMRI), ADC measurements and LVI to identify optimal predictive indicators.
Approach: Eighty-four patients rectal cancer underwent td-dMRI using OGSE and PGSE sequences. Four microstructural parameters and eight ADC measurements were assessed.
Results: Combination of intracellular volume fraction (ICVF), cellularity, and MRI-reported extramural venous invasion (EMVI) achieved the highest predictive performance for LVI.
Impact: The intracellular volume fraction (ICVF) from td-dMRI shows promise as a biomarker for LVI in rectal cancer. Combining ICVF and cellularity with MRI-reported EMVI enhances predictive performance, supporting clinicians in identifying high-risk patients for targeted treatment strategies.
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