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Abstract #2688

Histogram analysis of amide proton transfer imaging for predicting response to neoadjuvant chemoradiotherapy in rectal adenocarcinoma

Weicui Chen1, Wenjing Yuan1, Ziqi Jia1, Liyan Tang1, Jun Peng2, Kan Deng3, and Xian Liu1
1The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, 2Philips Healthcare, Guangzhou, China, 3Bayer Healthcare, Radiology, Guangzhou, China

Synopsis

Keywords: Digestive, MR Value

Motivation: Predicting response to neoadjuvant chemoradiotherapy (nCRT) is crucial for early stratified management of locally advanced rectal cancer (LARC) patients; however, current radiological studies remain inconclusive.

Goal(s): To investigate the potential of histogram analysis applied to pre-treatment amide proton transfer-weighted (APTw) imaging in predicting complete pathological regression (pCR) in patients with LARC undergoing nCRT.

Approach: Based on histologic assessment, the patients were divided into a pCR or a non-pCR group. APTw histogram features, apparent diffusion coefficient (ADC), and clinical parameters were analyzed.

Results: Histogram analysis of pre-treatment APTw may hold promise as a novel approach for predicting the response of LARC patients to nCRT.

Impact: Through the establishment of models and model comparison, the APTw-histogram model and the APTw-clinical combined model demonstrated strong diagnostic efficacy and clinical practicality in predicting LARC patients' responsiveness to nCRT, offering new insights for early clinical decision-making.

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