Abstract #2695

Intra- and Peri-tumoral Analysis with Multimodal Functional MRI for Preoperative Detection of Aggressive Endometrial Carcinoma in FIGO 2023

Jieying Zhang¹, Qi Zhang¹, Yuying Sun¹, Luyuan Li², Lizhi Xie³, Xiaoduo Yu¹, and Yan Chen¹

¹Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ²Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ³GE Healthcare, MR research China, Beijing, China

Synopsis

Keywords: Uterus, Quantitative Imaging, Perfusion

Motivation: Preoperative detection of aggressive endometrial carcinoma (EC) in the new 2023 FIGO system is essential for guiding surgical and fertility-preserving strategies, whereas pre‐ and postoperative tumor histological inconsistencies occur.

Goal(s): Our goal was to determine if multimodal functional MRI could detect aggressive from non-aggressive subtype of EC as defined in FIGO 2023.

Approach: We analyzed intra- and peritumoral parameters derived from intravoxel incoherent motion diffusion-weighted imaging, diffusion kurtosis imaging, and dynamic contrast-enhanced MRI between the two EC subtypes.

Results: A comprehensive multiparametric MRI protocol, incorporating clinical data, morphological features, and quantitative MRI parameters, performed well in detecting aggressive subtype EC preoperatively.

Impact: Multiparametric MRI, incorporating advanced quantitative sequences and conventional MRI features, could help effectively predict aggressive subtype EC in the FIGO 2023 system preoperatively, enhancing preoperative risk stratification and treatment planning in EC management.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.