Keywords: Pelvis, Body
Motivation: Accurate non-invasive assessment of rectal cancer microenvironment remains challenging.
Goal(s): Accurate non-invasive assessment of rectal cancer microenvironment remains challenging.
Approach: Prospective study of 63 rectal cancer patients using 3.0T MRI with restricted spectrum imaging (RSI) based diffusion-weighted imaging, correlating imaging findings with histopathology.
Results: RSI-derived parameters, particularly RSI3-C1 and RSI3-C2, showed significant associations with tumor stroma, Ki67 status, and differentiation. RSI3-C2 demonstrated highest accuracy for characterizing stroma status (AUC=0.763), while RSI3-C1 was best for Ki67 status (AUC=0.726) and differentiation (AUC=0.731).
Impact: RSI-derived parameters offer promising non-invasive biomarkers for characterizing rectal cancer microenvironment heterogeneity. This approach could enhance pre-treatment assessment, facilitate personalized treatment strategies, and improve patient outcomes. Further research may explore RSI's potential in treatment response prediction and monitoring.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords