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Abstract #2702

Determining the Metabolic Landscape of Pancreatic Cancer with Pharmacological Blockade of the Glutamine Transporter, ASCT2

Jose S. Enriquez1,2, Xiaoxia Wen1, Lin Tan3, Philip L. Lorenzi3, H. Charles Manning1,2, and Pratip K. Bhattacharya1,2
1Cancer System Imaging, UT MD Anderson Cancer Center, Houston, TX, United States, 2UT MD Anderson Cancer Center UT Health Science Center Houston Graduate School of Biomedical Sciences, Houston, TX, United States, 3Bioinformatics and Computational Biology, UT MD Anderson Cancer Center, Houston, TX, United States

Synopsis

Keywords: Pancreas, Metabolism, Pancreatic Cancer, Metabolic Imaging, Hyperpolarized MR

Motivation: The motivation of this study is to determine whether a metabolic inhibitor could be efficacious in treating pancreatic cancer.

Goal(s): The goal of this study is to employ magnetic resonance to image and study the biochemical pathways that a pancreatic cancer system utilizes to fuel and sustain its growth.

Approach: We have demonstrated the applications of HP MRS and NMR metabolomics to study the inhibition of glutamine pathway in pancreatic cancer.

Results: Employing metabolic imaging and metabolomics, we have demonstrated that glutamine inhibition changed the metabolic landscape of the cancer and is effective in arresting the tumor progression.

Impact: These results have demonstrated the potential of targeting the glutamine pathway for cancer therapy. Also how non-invasive techniques such as HP MRS can determine therapeutic efficacy in vivo leading to changes in therapy regiments.

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