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Abstract #2710

Natural history of simple T2-bright and complex T1-bright and diffusion restricting cysts in ADPKD

Caden Li1, Zhongxiu Hu1, and Martin R Prince1,2
1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States

Synopsis

Keywords: Biology, Models, Methods, biology, models, methods, ADPKD, Complex Cyst, Hemorrhage, Diffusion, T1-hyperdense, renal cyst

Motivation: Although kidney volume has been an established imaging biomarker for ADPKD classification and prognosis, the natural history of individual cyst growth remains unknown.

Goal(s): To identify the growth patterns of simple and complex cysts in ADPKD as defined by MRI T1, T2, and DWI contrasts and allow evaluation of treatment on a cyst level.

Approach: 124 individual cysts of 20 patients with an average 11-year follow-up were labeled by two experienced observers. Changes in cyst appearance on T1, T2, and DWI images and morphology were tracked over time.

Results: A model for ADPKD individual cyst growth cycle is presented.

Impact: This study investigated the natural history of cysts in ADPKD, establishing a model that characterizes ADPKD cyst growth, and shows the feasibility of staging ADPKD cysts using their MRI appearance.

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Keywords