Keywords: Kidney, CEST / APT / NOE, kidney, motion, fat, background model, olefinic, aliphatic
Motivation: APTw/CEST MRI in renal imaging would be useful for many ailments, such as characterization of small renal masses in cancer or kidney injury/transplants. However, fat and motion artifacts remain challenging.
Goal(s): Assess feasibility of in vivo fat-correction in renal CEST-MRI using previously introduced Z-spectral fitting of SPIR fat-suppressed data.
Approach: APTw/CEST data was acquired using single-shot fast-spin-echo MRI with compressed-sensing acceleration and timed-breathing in volunteers. Background model fitting (olefinic/aliphatic fat, water/MT, SPIR effect) is used for fat-correction in APTw imaging.
Results: Initial renal CEST-MRI using Z-spectral background-fitting was demonstrated with good suppression of fat and detailed substructure of CEST effect in the organ.
Impact: Enable CEST applications in the kidney with low artifact level from fat.
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