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Abstract #2713

Fat-corrected APTw/CEST-MRI with timed breathing for renal applications

Jochen Keupp1, Xiaojing Wang2, Ivan E. Dimitrov3,4, Holger Eggers1, and Elena Vinogradov2,4
1Philips Innovative Technologies, Hamburg, Germany, 2Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Philips Healthcare, Gainesville, FL, United States, 4Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: Kidney, CEST / APT / NOE, kidney, motion, fat, background model, olefinic, aliphatic

Motivation: APTw/CEST MRI in renal imaging would be useful for many ailments, such as characterization of small renal masses in cancer or kidney injury/transplants. However, fat and motion artifacts remain challenging.

Goal(s): Assess feasibility of in vivo fat-correction in renal CEST-MRI using previously introduced Z-spectral fitting of SPIR fat-suppressed data.

Approach: APTw/CEST data was acquired using single-shot fast-spin-echo MRI with compressed-sensing acceleration and timed-breathing in volunteers. Background model fitting (olefinic/aliphatic fat, water/MT, SPIR effect) is used for fat-correction in APTw imaging.

Results: Initial renal CEST-MRI using Z-spectral background-fitting was demonstrated with good suppression of fat and detailed substructure of CEST effect in the organ.

Impact: Enable CEST applications in the kidney with low artifact level from fat.

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Keywords