Abstract #2718

Altered Resting State Functional Connectivity Between High Order Cognitive and Low Level Perceptual Networks in posttraumatic stress disorder.

Ruihan Zhong¹, Yingxue Gao¹, Yingying Wang¹, Zilin Zhou¹, Weijie Bao¹, Lianqing Zhang¹, Hailong Li¹, Qiyong Gong^1,2,3, and Xiaoqi Huang^1,2,3

¹Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular lmaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China, ²Research Unit of Psychoradiology, Chinese Academy of Medical Science, Chengdu, China, Chengdu, China, ³The Xiamen Key Lab of Psychoradiology and Neuromodulation, West China Xiamen Hospital of Sichuan University, Xiamen, China, Chengdu, China

Synopsis

Keywords: Functional Connectivity, fMRI (resting state)

Motivation: Disease- and trauma-related alterations of functional connectivity within and between the high-order-cognitive networks (fronto-parietal, default-mode and salience network) and low-level-perceptual networks (auditory, visual and somato-motor network) in post-trauma stress disorder (PTSD) remains unclear.

Goal(s): To disentangle PTSD- and trauma-related alterations of high-order-cognitive and low-level-perceptual network.

Approach: We compared connectivity within and between high-order-cognitive and low-level-perceptual network among PTSD, trauma-exposed (TECs) and healthy controls via independent component analysis and seed-based functional connectivity (SBFC) analysis.

Results: we found PTSD patients showed hyperconnectivity within high-order-cognitive network (FPN-DMN and within FPN) and between high-order-cognitive and low-level-perceptual network (FPN-VN) compared to TECs.

Impact: Our results of dysfunction within and between different hierarchical network levels, with hyperconnectivity in high-order-cognitive network and between high-order-cognitive and low-level-perceptual network in PTSD were disease-related, which is associated with the key symptoms, potentially offering valuable targets for therapeutic interventions.

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