Abstract #2723

Sensory reweighting revealed by superior parietal lobule-based functional connectivity in chronic ankle instability

Rong Lu¹, Xiao’ao Xue², Shanshan Zheng³, Zikun Wang², Yushi Chen², Ziyuan Wang², Yuwen Zhang⁴, Weijun Tang¹, Tingfang Hwang¹, Ying-Hua Chu⁵, Qing Li⁵, Yang Sun², Yinghui Hua², and He Wang^6,7,8

¹Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China, ²Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China, ³Department of Sports Medicine, School of Exercise and Health, Shanghai University of Sport, Shanghai, China, ⁴Institute of Science and Technology for Brain-Inspired Intelligence, Fudan Universit, Shanghai, China, ⁵MR Research Collaboration, Siemens Healthineers Ltd., Shanghai, China, ⁶Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ⁷Human Phenome Institute, Fudan University, Shanghai, China, ⁸Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China

Synopsis

Keywords: Functional Connectivity, Brain Connectivity, Ankle Injuries; Postural Balance

Motivation: The study aimed to determine if connections between association cortex and sensory areas differ in Chronic ankle instability (CAI) patients versus controls, and whether these connections correlate with Romberg ratios in patients.

Goal(s): CAI involves postural control issues, possibly due to altered sensory integration from poor somatosensory feedback, but direct evidence of these changes is lacking.

Approach: The cross-sectional study used rs-fMRI to assess brain connectivity and balance, analyzing static and dynamic connectivity.

Results: CAI patients showed significantly higher Romberg ratios and functional connectivity compared to controls, with a notable inverse correlation between Romberg ratio and dynamic functional connectivity.

Impact: The findings suggest that clinicians may focus on somatosensory rehabilitation for CAI, which could mitigate visual over-reliance in patients. This study prompts further research into central mechanisms of sensory reweighting, influencing treatment strategies and improving outcomes for ankle sprain sufferers.

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