Abstract #2729

Distinct salience network dynamics between the imagery and the experience of migraine attacks

Inês Esteves¹, Alexandre Perdigão¹, Ana R. Fouto¹, Amparo Ruiz-Tagle¹, Gina Caetano¹, Joana Cabral^2,3, Isabel Pavão Martins⁴, Raquel Gil-Gouveia^5,6, César Caballero-Gaudes^7,8, and Patrícia Figueiredo¹

¹ISR-Lisboa and Department of Bioengineering, Instituto Superior Técnico – Universidade de Lisboa, Lisbon, Portugal, ²Life and Health Sciences Research Institute, University of Minho, Portugal, Braga, Portugal, ³Center for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Oxford, UK, Oxford, United Kingdom, ⁴Centro de Estudos Egas Moniz e Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa (FMUL), Lisbon, Portugal, Lisbon, Portugal, ⁵Neurology Department, Hospital da Luz, Lisbon, Portugal, Lisbon, Portugal, ⁶Center for Interdisciplinary Research in Health, Universidade Católica Portuguesa, Lisbon, Portugal, Lisbon, Portugal, ⁷Basque Center on Cognition, Brain and Language, Donostia - San Sebastian, Spain, Donostia - San Sebastian, Spain, ⁸Ikerbasque, Basque Foundation for Science, Bilbao, Spain, Bilbao, Spain

Synopsis

Keywords: Functional Connectivity, Brain

Motivation: Spontaneous migraine attacks are challenging to study and most research is performed during the interictal phase.

Goal(s): A pain imagery task may be able to elicit the migraine experience, even during the symptom-free phase, particularly impacting the salience network, which is linked to processing stimuli.

Approach: The dynamics of the salience network were studied across two phases of the migraine cycle, during and outside the migraine attack, and compared to matching healthy controls.

Results: Compared to controls, we observed lower mean lifetime for the salience network in patients during a pain imagery task in the interictal phase, but not during interictal/ictal resting state.

Impact: We found salience network dynamics alterations in migraine patients while performing an fMRI pain imagery task. These are, however, not observed during the occurrence of a migraine attack, which is likely more complex due to other neuronal and vascular changes.

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