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Abstract #2738

Repeatability of simultaneous 1H/23Na MR fingerprinting in knee cartilage at 7 T

Anne Adlung1, Dimitri Martel1,2, Baptiste Busi1, Gonzalo Gabriel Rodriguez3, Thorsten Kirsch4,5, Amparo Ruiz1,2, and Guillaume Madelin1
1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 2Department of Radiology and Tech4Health Institute, New York University Grossman School of Medicine, New York, NY, United States, 3NMR Signal Enhancement, Max Planck for Multidisciplinary Sciences, Gottingen, Germany, 4Department of Orthopedic Surgery, New York University Grossman School of Medicine, New York, NY, United States, 5Department of Biomedical Engineering, New York University Tandon School of Engineering, New York, NY, United States

Synopsis

Keywords: Quantitative Imaging, Non-Proton

Motivation: Simultaneous 1H/23Na MRF has potential for assessing pathologies in the knee cartilage.

Goal(s): This pilot study aims to evaluate the repeatability of simultaneous 1H/23Na MR fingerprinting (MRF) in knee cartilage of healthy subjects, to establish a baseline for spin densities and relaxation times.

Approach: We conducted four 3D 1H/23Na MRF acquisitions in six volunteers using a dual-tuned knee coil at 7T, obtaining sodium and proton maps through offline image reconstruction and MRF dictionary matching.

Results: The findings reveal good repeatability (CV around 10%) for proton T1, sodium density, T1, and T2l, while higher CV was observed in proton density, T1 and sodium T2s.

Impact: This is the first simultaneous acquisition of multinuclear MRF in knee cartilage at 7T. The pilot study indicates repeatability of measuring sodium and proton spin densities and relaxation times.

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Abstract

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