Abstract #2741

Quantitative Magnetization Transfer Mapping using Cardiac Magnetic Resonance Fingerprinting at 0.55T

Sydney Kaplan^1,2, Zhongnan Liu³, Jesse Hamilton^1,2, Shaihan Malik⁴, and Nicole Seiberlich^1,2

¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, ²Radiology, University of Michigan, Ann Arbor, MI, United States, ³Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, United States, ⁴Department of Imaging Physics and Engineering, Kings College London, London, United Kingdom

Synopsis

Keywords: MR Fingerprinting, Magnetization transfer, MR Fingerprinting, Low-Field MRI

Motivation: Accounting for MT effects may produce more accurate quantitative measurements and provide additional insights into myocardial disease.

Goal(s): To quantify bound and free water pool T₁ and T₂, bound pool fraction, and exchange rate in the heart using cMRF measurements.

Approach: cMRF data were simulated and collected at 0.55T using several maximum flip angles. Quantitative measurements were generated from these data both including and neglecting MT effects.

Results: Explicitly modeling MT effects yielded increased T₁ values and enabled mapping of T₁ and T₂ in the bound and free water pools, the bound pool fraction, and exchange rate in simulation and in vivo.

Impact: By modeling the effects of MT in cardiac Magnetic Resonance Fingerprinting, accurate measurements of the relaxation properties of free and bound water pools can be made, which may provide additional insight into the macromolecular make-up of the myocardium.

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