Abstract #2743

Comparing accelerated and conventional methods for brain T2 mapping: a quantitative NIST/ISMRM phantom study.

Jack J. Allen^1,2, Joely Smith^3,4, Stephen J. Wastling^2,5, Marzena Arridge^2,5, Anastasia Papadaki^2,5, Laura Mancini^2,5, Iulius Dragonu⁶, Tom Hilbert^7,8,9, John S. Thornton^2,5, Tarek Yousry^2,5, David L. Thomas⁵, and Matthew Grech-Sollars^1,2

¹Department of Computer Science, University College London, London, United Kingdom, ²Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, United Kingdom, ³Department of Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom, ⁴Department of Bioengineering, Imperial College London, London, United Kingdom, ⁵Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ⁶Research and Collaborations GB&I, Siemens Healthcare Ltd, Camberley, United Kingdom, ⁷Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, ⁸Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁹LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Synopsis

Keywords: Quantitative Imaging, Relaxometry, Quantitative MRI, T2 mapping

Motivation: Quantitative T2 is a biomarker of neuropathology but reliable measurement methods can be too slow for clinical use.

Goal(s): Identify fast and reliable methods for clinical brain T2 mapping.

Approach: Compare promising accelerated T2 mapping methods (GRAPPATINI and Magnetic Resonance Fingerprinting (MRF)) with conventional Dual-Echo Turbo Spin-Echo (DE-TSE) and Multi-Echo Spin-Echo (MESE) approaches. Where possible, spatial resolution and field of view was matched across the methods. However, MRF was limited to relatively large voxels.

Results: GRAPPATINI and MRF achieved reliable T2 measurements in reduced scan times compared to MESE. DE-TSE was faster but inaccurate.

Impact: Characterising rapid brain T2 mapping methods towards evaluating their clinical feasibility and potential to increase sensitivity to pathology compared to current clinical practice. This would aid patient-specific treatment by identifying subtle pathology and informing intervention decision-making.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.