Keywords: Quantitative Imaging, Quantitative Imaging
Motivation: MR Fingerprinting (MRF) is a prominent quantitative MRI technique known for its rapid and high-resolution data acquisition; however, it often demonstrates reduced accuracy in T2 quantification relative to T1.
Goal(s): To enhance T2 robustness to B0 and B1 inhomogeneities and mitigate motion artifacts.
Approach: Combined with B0, B1, and motion estimation, T2 preparation modules were integrated into a previously developed 3D FISP-MRF sequence to enhance T2 encoding, with Cramér-Rao Lower Bound optimization applied to both T2prep and flip angle (FA) parameters for further optimization.
Results: Phantom studies revealed enhanced T2 accuracy, while in-vivo studies demonstrated improved resilience to motion artifacts and B0/B1 inhomogeneities.
Impact: The improved T2 quantification accuracy and robustness to motion artifacts and field inhomogeneities could significantly enhance the reliability of MRF in both clinical and research settings.
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