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Abstract #2751

1mm Isotropic Resolution Whole Brain Microstructure Imaging at high SNR efficiency using 3D Multi-slab DMRI Demonstrated on the MAGNUS MRI

Chu-Yu Lee1 and Merry Mani2
1University of Iowa, Iowa City, IA, United States, 2University of Virginia, Charlottesville, VA, United States

Synopsis

Keywords: Data Acquisition, Acquisition Methods

Motivation: The motivation for the current work arises from the limitations of 3D multi-slab diffusion-weighted imaging (3D-msDWI), particularly its inability to support advanced microstructure studies due to its long volume acquisition times (VAT).

Goal(s): Develop a novel high SNR-efficiency signal generation and reconstruction framework based on 3D-msDWI that supports advanced microstructure studies at high spatial resolution.

Approach: Substantial reduction in VAT is achieved by sub-sampling 3D k-space. An aliasing-free reconstruction is designed by incorporating deep-learned priors to recover the volume data.

Results: The resulting framework is shown to generate 1mm isotropic 3-shell 66-direction data in 13min for the first time using 3D-msDWI acquisitions.

Impact: Addressing the long VAT of 3D-msDWI can provide a new technique to generate high SNR data that supports advanced microstructure studies.

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