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Abstract #2756

Simultaneous Myelin and Myelin Water Mapping Using Dual-Echo STAIR-Cones Sequence

James Lo1,2, Jiaji Wang1, Dylan Tran1, Jiyo S Athertya1, Soo Hyun Shin1, Jiang Du1,2,3, and Yajun Ma1
1Department of Radiology, University of California San Diego, La Jolla, CA, United States, 2Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, United States, 3Veteran Affairs San Diego Healthcare System, La Jolla, CA, United States

Synopsis

Keywords: Pulse Sequence Design, Acquisition Methods

Motivation: Myelin proton fraction (MPF) and myelin water fraction (MWF) measured with short-TR adiabatic inversion-recovery (STAIR) sequences are potential biomarkers of neurodegeneration but require two distinct sequences.

Goal(s): We aim to measure both the MPF and MWF with a single dual-echo (DE)-STAIR-Cones sequence.

Approach: Three volunteers were scanned with the DE-STAIR-Cones sequence for myelin and MW mapping, on a 3T clinical scanner.

Results: The single sequence successfully quantified the MPF, with and without decay correction, and the MWF with values comparable to those of previous studies.

Impact: The DE-STAIR-Cones, as a singular sequence, can measure the myelin imaging biomarkers of MPF and MWF, which may help in understanding the mechanism of these myelin imaging biomarkers for the assessment of neuroinflammatory/neurodegenerative diseases.

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Keywords