Keywords: Pulse Sequence Design, Acquisition Methods
Motivation: Myelin proton fraction (MPF) and myelin water fraction (MWF) measured with short-TR adiabatic inversion-recovery (STAIR) sequences are potential biomarkers of neurodegeneration but require two distinct sequences.
Goal(s): We aim to measure both the MPF and MWF with a single dual-echo (DE)-STAIR-Cones sequence.
Approach: Three volunteers were scanned with the DE-STAIR-Cones sequence for myelin and MW mapping, on a 3T clinical scanner.
Results: The single sequence successfully quantified the MPF, with and without decay correction, and the MWF with values comparable to those of previous studies.
Impact: The DE-STAIR-Cones, as a singular sequence, can measure the myelin imaging biomarkers of MPF and MWF, which may help in understanding the mechanism of these myelin imaging biomarkers for the assessment of neuroinflammatory/neurodegenerative diseases.
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