Meeting Banner
Abstract #2797

Surface Modeling of Dynamic Contrast-Enhanced MRI Enables Individualized Diagnosis of Gastric Dysmotility in Gastroparesis

Xiaokai Wang1, Fatimah Alkaabi1, Yiwei Xia1, Cindy Yang2, and Zhongming Liu1,2
1Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 2Electrical and Computer Engineering, University of Michigan, Ann Arbor, MI, United States

Synopsis

Keywords: Digestive, Digestive, Stomach, Gastroparesis, Diabetes, Personalized Diagnosis

Motivation: Gastroparesis patients have diverse underlying pathophysiology but present overlapping symptoms, complicating effective diagnosis and treatment.

Goal(s): This study aims to demonstrate how surface modeling of dynamic contrast-enhanced MRI can provide non-invasive and individualized diagnosis of gastroparesis.

Approach: Gastroparesis patients and healthy controls consumed a manganese-enriched test meal with natural ingredients. During digestion, T1-weighted MRI captured dynamic images of the stomach every 3 s. Surface modeling captured stomach wall motion, providing individualized dysmotility phenotypes relative to healthy controls.

Results: Our results revealed diverse patterns of gastric dysmotility in terms of amplitude, frequency, and propagation of muscle contractions among patients with different and similar etiology.

Impact: Our novel MRI-based technique enables precise quantification of gastric motor dysfunctions, providing a non-invasive tool for individualized and evidence-based diagnosis of gastroparesis to inform tailored treatment for potentially better patient outcomes.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords