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Abstract #2802

Free-breathing quantitative blood oxygen level-dependent (qBOLD) MRI of the healthy adult pancreas during oral glucose stimulation

Anna M Horner1, Marcel Dominik Nickel2, Vahid Khalilzad Sharghi3, Lisa Staimez4, Priyathama Vellanki1,5, and David A Reiter6,7,8
1Emory University School of Medicine, Atlanta, GA, United States, 2Siemens Healthineers AG, Forchheim, Germany, 3Siemens Healthineers, Atlanta, GA, United States, 4Rollins School of Public Health, Emory University, Atlanta, GA, United States, 5Grady Memorial Hospital, Atlanta, GA, United States, 6Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 7Biomedical Engineering, Emory University School of Medicine and Georgia Technical Institute, Atlanta, GA, United States, 8Orthopedics, Emory University School of Medicine and Georgia Technical Institute, Atlanta, GA, United States

Synopsis

Keywords: Pancreas, Pancreas, Oxygenation, Perfusion, Diabetes

Motivation: Current clinical standards for diagnosing diabetes are indirect and mostly sensitive to late disease stages. For early detection and intervention, a marker is needed to directly observe declines in beta-cell function.

Goal(s): Quantitative blood oxygen level-dependent (qBOLD) MRI shows promise as a non-invasive, direct clinical metric of pancreatic function. Prior work utilizing a breath-hold protocol has revealed challenges with applying this dynamic imaging to the pancreas.

Approach: We hope to address these issues by using a free-breathing motion-corrected qBOLD technique.

Results: Healthy volunteers displayed decreases in T2* values after glucose ingestion. T2* fits were comparable to breath-hold acquisitions with reduced segmentation time.

Impact: Our results support the feasibility of a free-breathing protocol for functional pancreatic imaging as a more executable approach for patient populations, providing improved resource efficiency, i.e., reduced patient burden and lower processing costs compared to current breath-hold techniques.

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