Abstract #2807

Complementary role of diffusion kurtosis imaging combined with amide proton transfer-weighted imaging for VI-RADS

Fang Wang¹, Xinghua Xu¹, Lingyu Chang², Liang Du², Ying Xu¹, Dmytro Pylypenko³, Tianyong Xu⁴, Xiangshui Meng², Dexin Yu¹, and Qing Wang¹

¹Qilu Hospital of Shandong University, Jinan city, Shandong province, China, ²Qilu Hospital (Qingdao) of Shandong University, Qingdao city, Shandong province, China, ³GE Healthcare, MR Research China, Beijing, China, ⁴GE Healthcare, MR Application China, Shanghai, China

Synopsis

Keywords: Urogenital, Bladder, Amide proton transfer-weighted imaging; diffusion kurtosis imaging; bladder cancer; muscle invasion; vesical imaging reporting and data system

Motivation: Precise preoperative evaluation of the muscular invasion of bladder cancer (MIBC) could guide proper
treatment and predict prognosis in clinical practice.

Goal(s): Determine the feasibility of diffusion kurtosis imaging (DKI) and amide proton transfer-weighted imaging (APTw) parameters in differentiating MIBC from non-MIBC (NMIBC) and its potential gain effect in vesical imaging reporting and data system (VI-RADS).

Approach: A total of 69 patients underwent preoperative MRI.

Results: The DKI parameters and APTw values were significantly different in MIBC and NMIBC groups. The combined DKI and APTw model had the highest AUC values and complemented the VI-RADS.

Impact: Our results demonstrate that the promising potential of this combined model for the preoperative assessment of muscle invasion in BC as well as being a complement to VI-RADS.

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