Meeting Banner
Abstract #2812

Development and validation of a preoperative MRI habitat radiomics model to predict variant histology in bladder cancer

Lingmin Kong1, Yanjin Qin1, Qian Cai1, Keyi Zhang1, Xueying Zhao2, Yan Guo3, and Huanjun Wang3
1Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China, 2MR Research, GE Healthcare, Beijing, China, 3The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

Synopsis

Keywords: Cancer, Bladder, variant histology

Motivation: Bladder cancer (BCa) patients with variant histology (VH) exhibit more aggressive tumor characteristics, resulting in poor prognosis and resistance to neoadjuvant therapy. Accurate assessment of VH is challenging due to biological complexity and limited biopsy samples.

Goal(s): To identify VH in BCa and predict patient prognosis.

Approach: An MRI-based fusion model that combines habitat radiomics, clinicopathologic variables, and conventional radiomics was developed, using data from 764 bladder cancer patients across four institutions.

Results: The proposed model demonstrated high predictive accuracy (AUC 0.895-0.974) across multiple cohorts, with low-risk patients showing better disease-free survival and higher pathological complete response rates.

Impact: The proposed VHRiS model represents a promising and robust tool forto identifying variant histologyVH, offering providing valuable insights into patient prognosis within the microtumoral environment and suggesting indicating potential benefit for precision clinical decision-making guidance in patients with bladder cancer.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords