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Abstract #2815

Coarctation of the urethra? A pilot study of MRI based computational fluid dynamic study of urethral biomechanics in urethral stricture

Evan John Turner1, Juan Pablo Gonzalez-Pereira1, Madison Taychert2, Matthew Grimes2, and Alejandro Roldan-Alzate1,3
1Mechanical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 2Urology, University of Wisconsin - Madison, Madison, WI, United States, 3Radiology, University of Wisconsin - Madison, Madison, WI, United States

Synopsis

Keywords: Urogenital, Urogenital, Urethra, CFD, WSS

Motivation: USD patients are currently evaluated with RUG which provides limited information. USD patients cannot undergo UDS studies to evaluate their bladder or urethral function given their obstruction.

Goal(s): To develop a non-invasive MRI based CFD tool to comprehensively evaluate the LUT in USD patients.

Approach: One healthy volunteer and two USD patients were imaged with our MRI urodynamic protocol and a voiding event was simulated with CFD.

Results: USD patients demonstrated higher urine velocities, increased wall shear stress, and pressure gradients across the strictured segment compared to non strictured urethras relative to flow.

Impact: USD patients are currently restricted in which methods can be employed to evaluate their bladder/urethral function. This study develops a non-invasive MRI based CFD tool to rigorously evaluate the LUT in USD patients.

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