Keywords: Pelvis, Cancer
Motivation: There is a strong correlation of Ki-67 overexpression with unfavorable prognosis and rapid rectal carcinoma progression.
Goal(s): To investigate the significance of virtual MRE (vMRE) and fractional-order calculus (FROC) in assessing the proliferative status of rectal carcinoma.
Approach: A total of 66 rectal carcinoma patients were enrolled. MRI scans were performed with a commercial 3.0T scanner equipped with a 30-channel phased-array body coil.
Results: The patients with high-proliferation rectal carcinoma exhibited significantly higher µMRE and μ and significantly lower ADC, D, and β than those with low-proliferation rectal carcinoma. LR analysis showed that µMRE, D, and β were independent predictors.
Impact: The vMRE, FROC, and DWI can effectively differentiate between high- and low-proliferation rectal carcinoma. and a composite diagnostic tool consisting of µMRE, D, and β may serve as a promising biomarker to help make optimal clinical decisions.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords