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Abstract #2825

Virtual magnetic resonance elastography and fractional order calculus model for assessing proliferation status in rectal carcinoma

Nan Meng1, Yingying Cui1, Xinhui Wang1, Xiaoxu Chen1, Jinxia Guo2, Lizhi Xie2, and Meiyun Wang1
1Department of Radiology, Henan Provincial People’s Hospital & Zhengzhou University People’s Hospital, Zhengzhou, China, 2MR Research China, GE Healthcare, Beijing, China

Synopsis

Keywords: Pelvis, Cancer

Motivation: There is a strong correlation of Ki-67 overexpression with unfavorable prognosis and rapid rectal carcinoma progression.

Goal(s): To investigate the significance of virtual MRE (vMRE) and fractional-order calculus (FROC) in assessing the proliferative status of rectal carcinoma.

Approach: A total of 66 rectal carcinoma patients were enrolled. MRI scans were performed with a commercial 3.0T scanner equipped with a 30-channel phased-array body coil.

Results: The patients with high-proliferation rectal carcinoma exhibited significantly higher µMRE and μ and significantly lower ADC, D, and β than those with low-proliferation rectal carcinoma. LR analysis showed that µMRE, D, and β were independent predictors.

Impact: The vMRE, FROC, and DWI can effectively differentiate between high- and low-proliferation rectal carcinoma. and a composite diagnostic tool consisting of µMRE, D, and β may serve as a promising biomarker to help make optimal clinical decisions.

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