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Abstract #2827

In-vivo detection of rectal cancer at low field using field cycling imaging

Amnah Saad Alamri1,2, Nicholas Senn1, Leslie Samuel3, Rosalind Mitchell-Hay4, David Lurie1, George Ramsay4, and Lionel Broche1
1School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom, 2Department of Radiologic Sciences, King Abdulaziz University, Jeddah, Saudi Arabia, 3Department of Oncology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 4Aberdeen Royal Infirmary, Aberdeen, United Kingdom

Synopsis

Keywords: Digestive, biomarkers, Rectal cancer, FFC, Low-field, treatment response

Motivation: Fast Field-Cycling (FFC) provides insights into molecular dynamics and non-invasive tumour biomarkers using low magnetic fields. Our pilot study suggests that FFC technique may improve colorectal cancer detection by studying the 1H NMRD profiles.

Goal(s): This study aims to assess FCI feasibility for detecting rectal cancer and predicting response to neoadjuvant chemoradiotherapy.

Approach: Rectal cancer patients were scanned by FCI scanner. We used a saturation recovery spin echo sequence with four evolution fields (200, 20, 2, and 0.2 mT).

Results: The results showed higher R1 values (1/T1) and steeper slopes in rectal tumour at lower fields. NMRD profiles indicated reduced R1 in responders.

Impact: This FFC-NMRD technique could complement existing imaging modalities by addressing limitations in detecting post-therapy changes in rectal cancer, enabling non-invasive diagnostics. Also, it holds potential to improve personalized treatment, guiding more effective therapies and enhancing patient outcomes.

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Keywords