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Abstract #2829

T1-Mapping with High-Spatial-Resolution T2-Weighted Imaging Differentiates Mucinous from Nonmucinous Adenocarcinoma in Rectal Cancer

Yiyan Liu1, Ziqiang Wen1, Yan Chen1, Shenping Yu1, Yuru Ma1, Xinyue Yang2, and Yunzhu Wu3
1The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, 2Zhujiang Hospital, Southern Medical University, Guangzhou, China, 3School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China

Synopsis

Keywords: Digestive, Quantitative Imaging, Magnetic resonance imaging; mucinous adenocarcinoma; rectal cancer; T1-mapping

Motivation: Differentiating mucinous adenocarcinoma (MC) from adenocarcinoma not otherwise specified (AC) is crucial due to distinct prognostic and treatment responses.

Goal(s): To assess high-spatial-resolution T2-weighted imaging (HR-T2WI) and T1-mapping effectiveness in distinguishing MC from AC in rectal cancer.

Approach: In this prospective study of 92 patients (55 AC, 37 MC), radiologists assessed HR-T2WI scans, and pre- and post-contrast T1 relaxation times were measured. Diagnostic efficacy was evaluated using receiver operating characteristic curve analysis.

Results: HR-T2WI achieved 81.08% sensitivity and 94.55% specificity. The combined HR-T2WI and T1p model yielded a 0.927 area under the curve, improving diagnostic performance over individual techniques

Impact: This study suggests combining HR-T2WI and T1-mapping as a non-invasive method for diagnosing MC in rectal cancer, potentially reducing false-negative biopsies. Future research can explore its role in treatment response prediction and outcome assessment.

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