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Abstract #2833

Assessing Liver Fibrosis with Gd-EOB-DTPA-enhanced B1 Inhomogeneity-corrected VFA T1 mapping: Comparison with US Shear-wave Elastography

Yang Li1 and Caixia Fu2
1Department of Radiology,Zhongshan Hospital of Fudan University, Shang hai, China, 2MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, Shenzhen, China

Synopsis

Keywords: Liver, Liver, fibrosis, Gd-EOB-DTPA, T1 mapping,US shear-wave elastography

Motivation: Accurate assessment of liver fibrosis is crucial to determine management and mitigate complications of patients with chronic liver disease.

Goal(s): This study aimed to compare the performance of Gd-EOB-DTPA-enhanced B1 inhomogeneity-corrected variable flip angle (VFA) T1 mapping and liver stiffness measurement (LSM) using US shear-wave elastography (SWE) for detecting and staging liver fibrosis

Approach: We prospectively compared liver T1 relaxation times of Gd-EOB-DTPA-enhanced B1 inhomogeneity-corrected variable VFA T1 mapping and LSM in 97 patients.

Results: Our results showed the area under the curve of LSM was significantly higher than those of T1 relaxation times for advanced fibrosis and cirrhosis.

Impact: It is essential to apply a noninvasive and accurate method for predicting liver fibrosis stages. Liver stiffness measurement using US shear-wave elastography is superior to T1 relaxation times obtained from Gd-EOB-DTPA-enhanced T1 mapping for staging liver fibrosis.

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