Meeting Banner
Abstract #2838

Correlation of MRE-Based Liver and Spleen Stiffness with Platelet Count in Chronic HBV Infection Patients

Hailong Zhang1, Zhuoru Jiang2, Xiance Zhao3, Jie Li2, Bing Zhang1, and Jun Chen1,4
1Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing,Jiangsu, China, 2Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing,Jiangsu, China, 3Philips Healthcare, Shanghai, China, 4Department of Radiology, Mayo Clinic, Rochester, MN, United States

Synopsis

Keywords: Liver, Liver, Spleen, Magnetic resonance elastography; Hepatitis B

Motivation: The correlation between changes in liver and spleen biomechanical properties and platelet count remains unclear in chronic hepatitis B virus (HBV) infection patients.

Goal(s): To investigate the correlation between the three parameters: liver stiffness, spleen stiffness, and platelet count.

Approach: Magnetic resonance elastography was used to measure liver and spleen stiffness. Blood platelet count was recorded. The association was evaluated by the Spearman correlation.

Results: The results showed a statistically significant positive correlation between liver stiffness and spleen stiffness. Conversely, there was a statistically significant negative correlation between liver stiffness and platelet count, as well as between spleen stiffness and platelet count.

Impact: Our study revealed the consistency of changes in the biomechanical properties of the liver and spleen during the liver fibrosis progression of chronic HBV infection. Furthermore, we demonstrated their correlation with thrombocytopenia.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords