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Abstract #2842

Comparative Assessment of Hepatic T2, T2*, and PDFF Estimates from Breath-Hold and Free-Breathing Respiratory-Gated Acquisitions

Anandh Kilpattu Ramaniharan1, Justine Kemp1,2, Murat Kocaoglu1,2, Josh Greer2,3, Jean Tkach1,2, Andrew Trout1,2, Jonathan Dillman1,2, Amol Pednekar1,2, and Mary Kate Manhard1,2
1Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States, 3Philips North America, Cincinnati, OH, United States

Synopsis

Keywords: Liver, Liver, Liver, quantitative imaging, relaxometry, MRI, free breathing

Motivation: Breath-hold (BH) acquisitions pose challenges for some patients, often requiring repeated scans or resulting in degraded images due to respiratory motion artifacts.

Goal(s): To evaluate the effectiveness of free-breathing respiratory-gated (RG) versus BH acquisitions of mGRASE for T2 mapping and mDIXON Quant for T2* and PDFF mapping.

Approach: T2, T2*, and PDFF measurements were obtained from both BH and RG acquisitions in participants with and without liver disease and were statistically compared.

Results: T2, T2*, and PDFF estimates from RG acquisitions demonstrated excellent agreement (ICC>0.92) with BH acquisitions in 19 participants (ages 9-28), with no statistically significant differences between the two methods.

Impact: Respiratory-gated mGRASE and mDIXON Quant acquisitions produced T2, T2*, and PDFF estimates with excellent agreement to estimates from breath-hold acquisitions. This approach suggests applicability for liver assessments in patients with impaired breath-holding capacity, particularly young children or patients with comorbidities.

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Abstract

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