Abstract #2848

Free-breathing hepatic Oxygen Extraction Fraction (OEF) mapping using radial GESSE

Ke Zhang^1,2, Simon M. F. Triphan^1,2, Felix T. Kurz³, Christian H. Ziener⁴, Mark E. Ladd⁵, Heinz-Peter Schlemmer⁴, Hans-Ulrich Kauczor^1,2, and Oliver Sedlaczek^1,4

¹Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany, ²Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany, ³Division of Neuroradiology, Geneva University Hospitals, Geneva, Switzerland, ⁴Division of Radiology, German Cancer Research Center, Heidelberg, Germany, ⁵Division of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany

Synopsis

Keywords: Liver, Oxygenation

Motivation: Non-invasive hepatic oxygenation mapping has been limited to single slice and single breath-hold.

Goal(s): Multi-slice mapping of hepatic oxygenation in free-breathing is needed.

Approach: In this study, hepatic oxygen extraction fraction (OEF) was measured using a radial gradient-echo sampling of spin-echo (rGESSE) sequence to cover multiple liver slices and be robust against respiratory motion. For OEF analysis, a feedforward artificial neural network (ANN) was used.

Results: This study demonstrates the feasibility of radial GESSE to measure hepatic OEF.

Impact: The feasibility of free-breathing liver OEF mapping using rGESSE was investigated. Further improvement of the quantification, possibly using measured macroscopic field inhomogeneities may be needed.

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