Abstract #2853

Abnormal Low Frequency Fluctuations and Functional Connectivity in Overactive Bladder Syndrome

Shichun Chen¹, Zongpai Zhang¹, Yakun Zhang¹, Kenneth Wengler², Justina Tam³, Steven Weissbart³, Weiying Dai¹, and Xiang He⁴

¹Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, ²New York State Psychiatric Institute, New York, NY, United States, ³Urology, State University of New York at Stony Brook, Stony Brook, NY, United States, ⁴Radiology, North Shore University Hospital, Northwell Health, Manhasset, NY, United States

Synopsis

Keywords: Functional Connectivity, Functional Connectivity, Overactive bladder

Motivation: Overactive Bladder (OAB) significantly affects patients' quality of life. However, the exact mechanism of brain-bladder control in urinary continence remains unclear.

Goal(s): To investigate the abnormality of amplitude of low-frequency fluctuations (ALFF) and functional connectivity (FC) during the bladder filling in OAB patients.

Approach: Blood oxygenation level-dependent (BOLD) images were acquired at bladder filling volumes of 0, 50, 100, 200, 350 and 500mL.

Results: We observed comprised ALFF in the orbitofrontal cortex and medial prefrontal cortex (mPFC), along with disrupted FC between posterior cingulate cortex (PCC) and mPFC and between mPFC and pDMN in OAB patients during bladder filling.

Impact: We provide new insights into the roles of FC and ALFF in controlling urinary incontinence. This study demonstrated that FC and ALFF may serve as potential biomarkers for monitoring treatment effects in OAB patients.

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