Abstract #2858

Resting-state BOLD fMRI cerebrovascular reactivity in youth with congenital heart disease

Zacharie Potvin-Jutras^1,2,3, Safa Sanami^1,2,3, Kaitlyn Easson^4,5, Guillaume Gilbert⁶, Christine Saint-Martin⁷, Christopher J. Steele^3,8,9, Marie Brossard-Racine^4,5,10,11, and Claudine J. Gauthier^1,2,3

¹Physics Department, Concordia University, Montreal, QC, Canada, ²Centre Epic and Research Center, Montreal Heart Institute, Montreal, QC, Canada, ³School of Health, Concordia University, Montreal, QC, Canada, ⁴Advances in Brain & Child Development (ABCD) Research Laboratory Research Institute of the McGill University, Health Centre, Montreal, QC, Canada, ⁵Department of Neurology & Neurosurgery, Faculty of Medicine & Health Sciences McGill University, Montreal, QC, Canada, ⁶MR Clinical Science Philips Healthcare, Mississauga, ON, Canada, ⁷Department of Medical Imaging Montreal Children's Hospital Montreal, Division of Pediatric Radiology, Montreal, QC, Canada, ⁸Department of Psychology, Concordia University, Montreal, QC, Canada, ⁹Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ¹⁰Division of Neonatology, Department of Pediatrics Montreal Children's Hospital, Montreal, QC, Canada, ¹¹School of Physical & Occupational Therapy, Faculty of Medicine and Health Sciences McGill University, Montreal, QC, Canada

Synopsis

Keywords: fMRI Analysis, fMRI (resting state), Cerebrovascular reactivity

Motivation: Cerebrovascular reactivity (CVR) has never been studied in congenital heart disease (CHD), likely due to safety concerns and low practicality related to the conventional stress challenge. Recently, a gas-free manipulation CVR technique has been developed.

Goal(s): Thus, this study aimed to investigate CVR in youth with CHD, assessing the influence of sex and type of surgery.

Approach: CVR was measured from resting-state functional magnetic resonance imaging without gas or breathing manipulations.

Results: Overall, results showed lower regional relative CVR in youth with CHD compared to controls in the anterior cerebral artery territory, with females and those with single-ventricle physiology exhibiting lower relative CVR.

Impact: We observed lower cerebrovascular reactivity (CVR) in youth with congenital heart disease (CHD), with those with single-ventricle physiology most affected, especially in the anterior cerebral artery territory. Females with CHD revealed poorer CVR in the middle cerebral artery territory.

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