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Abstract #2862

Altered white matter functional networks in type 2 diabetes mellitus with and without mild cognitive impairment

Yang Huang1, Dongsheng Zhang1, Xin Zhang1, Xiaoyan Lei1, Xiaoling Zhang1, and Kai Ai2
1Shaanxi Provincial People's Hospital, Xi 'an, China, 2Department of Clinical and Technical Support, Philips Healthcare, Xi 'an, China

Synopsis

Keywords: Functional Connectivity, fMRI (resting state)

Motivation: Cognitive impairment in T2DM is associated with functional network disruption in gray matter and structural abnormalities in white matter (WM), but the functional information in WM is unknown.

Goal(s): This study aimed to characterize the WM functional network changes in patients with T2DM under different cognitive states.

Approach: 221 T2DM (121 DMCI and 100 DMNC) and 122 HC underwent neuropsychological assessment and rs-fMRI examinations. The functional connectome and global topological properties of WM functional network were calculated.

Results: The DMCI exhibited more extensive disorders functional connectome of WM network, and showed lower cluster coefficient and local efficiency, and higher path length.

Impact: This study explored the change patterns of WM functional connectome and global topological properties in patients with T2DM under different cognitive states, which can provide a neuroimaging basis for revealing T2DM-related brain damage from the perspective of WM function.

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