Keywords: fMRI Analysis, Degenerative
Motivation: Glaucoma causes progressive degeneration throughout the visual pathway. While structural atrophy has been well-documented, a comprehensive analysis that includes both structural and functional impairments remains essential.
Goal(s): To evaluate structural atrophy and functional changes in cytoarchitectonic areas along the visual stream, including the lateral geniculate nucleus (LGN), visual cortex (hOc1-4), and fusiform gyrus (FG1-4), in glaucoma patients.
Approach: Structural and functional MRI was employed to assess brain volume and functional responses in healthy controls, early glaucoma, and advanced glaucoma groups.
Results: The study identified volumetric shrinkage exclusively in the LGN, with functional impairments observed across the LGN, hOc1-4, and FG1 regions.
Impact: Our findings suggest that functional impairments are more pronounced than structural changes in the visual pathway, including the LGN, visual cortex, and fusiform gyrus, in glaucoma. This highlights the importance of studying functional impairments in higher-level visual areas in glaucoma.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords