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Abstract #2874

Improved 3-T MRI Proximal Femur Microarchitecture Parameters Correlate with Higher DEXA Bone Mineral Density T-Scores

Andrew Clayburn1,2, Xiaoliu Zhang3, Anmol Monga1, Stephen Honig1, Chamith Rajapakse4, Punam Saha3, and Gregory Chang1
1New York University Grossman School of Medicine, New York, NY, United States, 2Dell Medical School at the University of Texas in Austin, Austin, TX, United States, 3University of Iowa, Iowa City, IA, United States, 4University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Data Processing, preclinical image analysis, Osteoporosis, Pulse Sequence Design, Quantitative Imaging, Screening, Segmentation

Motivation: Current osteoporosis diagnostics, primarily reliant on DEXA-assessed BMD, have limited sensitivity. This study addresses the need for markers that assess bone quality beyond BMD for improved fracture risk assessment.

Goal(s): To determine the relationship between MRI-derived femoral microarchitecture metrics and DEXA BMD T-scores in post-menopausal women.

Approach: This prospective, observational study correlated DEXA T-scores with 3-T MRI-derived femoral microarchitecture parameters to identify strength of association.

Results: Significant correlations were found between DEXA-derived BMD T-scores and MRI-derived femur microarchitecture parameters.

Impact: This study suggests that MRI metrics of bone microarchitecture could complement DEXA in osteoporosis assessment, together offering a more comprehensive tool to improve fracture risk prediction and enhance patient-specific treatment strategies for osteoporosis.

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Keywords