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Abstract #2887

Agreement of vendor software tools for placental diffusion coefficient maps in normal and hypertensive pregnancies

Yin Xi1, Christina L. Herrera2,3, Quyen N. Do1, David Owen2,3, Catherine Y. Spong2,3, Baowei Fei1,4,5, Diane M. Twickler1,3, and Matthew A. Lewis1
1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, TX, United States, 3Obstetrics and Gynecology, Parkland Health, Dallas, TX, United States, 4Bioengineering, The University of Texas at Dallas, Richardson, TX, United States, 5Center for Imaging and Surgical Innovation, Richardson, TX, United States

Synopsis

Keywords: Placenta, Diffusion Software

Motivation: The complexity of the human placenta and the impact of chronic hypertension (cHTN) on pregnancy outcomes necessitate a deeper understanding and reliable imaging methods.

Goal(s): This study aimed to evaluate the agreement of diffusion coefficients derived from various fit algorithms provided by two vendor-specific software in pregnancies with and without cHTN.

Approach: We conducted a 3T MRI study on 39 pregnancies, including healthy and cHTN cases, calculating diffusion coefficients using multiple models and parameter estimation algorithms. Agreement and bias were assessed through Intraclass Correlation Coefficients and Bland-Altman analysis.

Results: Strong agreement was observed within similar models, while agreement across vendors was generally moderate.

Impact: Choice of diffusion models significantly affects diffusion coefficients estimation. Consistent methodologies in placental diffusion imaging are crucial for reliable comparisons and generalizable clinical interpretation.

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Keywords