Abstract #2899

Comparison of denoising methods for dynamic deuterium MRSI at 7T

Anna Duguid¹, Wolfgang Bogner^1,2, Fabian Niess¹, Lukas Hingerl¹, Viola Bader¹, Sabina Frese¹, Aaron Osburg¹, Martin Krššák³, Bernard Lanz^4,5, Brayan Alves^4,5, Cristina Cudalbu^4,5, and Bernhard Strasser¹

¹High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK), Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Department of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria, ⁴CIBM Center for Biomedical Imaging, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁵Animal Imaging and Technology, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Synopsis

Keywords: Deuterium, Deuterium, Low-Rank Denoising, Deuterium Metabolic Imaging, Spectroscopy

Motivation: Dynamic deuterium (²H) MRSI is a promising technique for mapping metabolic fluxes. However, achieving adequate spatiotemporal resolution is challenging due to its inherently low SNR.

Goal(s): This work compares four low-rank denoising strategies for dynamic ²H-MRSI: Spatiotemporal-based low-rank approximation (ST), global-local higher-order singular value decomposition (GLHOSVD), and Mixed and Stacked ST, which reshape the 5D array into a matrix before denoising.

Approach: Each denoising method was tested on simulated and in vivo dynamic ²H-MRSI brain data.

Results: All methods reduced noise variation in the metabolite maps. GLHOSVD and Mixed denoising mostly preserved regional physiological variations, whereas ST and Stacked ST substantially degraded them.

Impact: Our work helps identify a denoising algorithm for dynamic ²H-MRSI that achieves high denoising performance while preserving regional variations. The achieved reductions in metabolite concentration uncertainty may enable high-resolution, whole-brain dynamic ²H-MRSI, to investigate oxidative and non-oxidative human brain metabolism.

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