Abstract #2901

High Resolution Dynamic Deuterium MRS Imaging of Cerebral Glucose Metabolism in Mouse Brain at Ultrahigh Field of 16.4T

Abbas Monsef^1,2, Xiao-Hong Zhu¹, Chao Zou¹, Tao Wang¹, Kelsey Haney¹, Yudu Li^3,4,5, Zhi-Pei Liang^4,6, and Wei Chen¹

¹Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ²Department of Medical Physics, Radiation Oncology, University of Minnesota, Minneapolis, MN, United States, ³Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁶Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Synopsis

Keywords: Deuterium, Deuterium, High-resolution, MRSI, Spectroscopy, Brain, Metabolism

Motivation: Motivation:Deuterium MRS imaging (²H-MRSI) is valuable for mapping brain deuterated metabolites, but its low sensitivity and poor imaging resolution make it particularly challenging to image the mouse brain.

Goal(s): Goal:To study glucose metabolism in mouse brain using dynamic ²H-MRSI with high spatiotemporal resolution.

Approach: Approach:Dynamic 3D ²H-MRSI was performed on mice brains at 16.4T with an intraperitoneal administration of deuterium labeled glucose; SPICE denoising was applied to further enhance SNR.

Results: Results:We achieved highest spatiotemporal resolution ²H-MRSI (3μL voxel size and 2.5min) with excellent SNR, enabling imaging of low concentration metabolites and their dynamics in the mouse brain.

Impact: This work demonstrates the capability of high-resolution 2H-MRSI for mapping deuterated metabolites and dynamics in the mouse brain with excellent sensitivity. It highlights the potential of studying cerebral glucose metabolism in various mouse models of genetic or other diseases.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.