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Abstract #2906

An Integrated 1H/2H Multichannel Head Coil for Improved Deuterium Metabolic Imaging

Anna Bennett Haller1,2, Adam Autry1, Michael Vaeggemose3,4, Lucas Carvajal1, Chunsheng Wang5, Huilou Liang6, Yu Zhao7, Christoffer Laustsen3, Yan Li1, David M Wilson1, Duan Xu1, and Jeremy W Gordon1
1Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2UC Berkeley-UCSF Graduate Program in Bioengineering, San Francisco, CA, United States, 3Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 4GE HealthCare, Brondby, Denmark, 5Magtron Inc, Jiangyin, China, 6MR Research, GE HealthCare, Beijing, China, 7West China Hospital, Sichuan University, Chengdu, China

Synopsis

Keywords: Deuterium, Deuterium, CSI, DMI, Multichannel Coil

Motivation: To improve deuterium metabolic imaging (DMI) sensitivity at 3T.

Goal(s): Characterize and test an 8Ch 1H / 16Ch 2H head coil.

Approach: Deuterium (2H) CSI data were acquired with the 8Ch 1H / 16Ch 2H head coil and compared to a 1H/2H quadrature volume transceiver in one water phantom. DMI data were also acquired in one patient with glioblastoma after administering 2H-glucose.

Results: SNR images demonstrated the deuterium 16Ch coil improves SNR by 2.5-fold at the periphery and 1.6-fold at the phantom center relative to 1H/2H quadrature coil. Glioma patient data demonstrated improved SNR, highlighting localized reduction in Glx and resolvable lactate signal.

Impact: Improved SNR in 3T DMI with an integrated 1H/2H multichannel array coil has the potential to greatly improve the detection of impaired glucose metabolism and regional differences in brain disease diagnosis.

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Abstract

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