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Abstract #2912

Effects of nicotinamide riboside supplementation on glucose metabolism and lipid homeostasis in healthy mice

Anshuman Swain1, Narayan Datt Soni1, Sunil Kumar Khokhar1, Halvor Juul1, Paul Jacobs1, Ravi Prakash Reddy Nanga1, Mohammad Haris1, and Ravinder Reddy1
1Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Deuterium, Treatment Response, DMRS, CEST/MT, NAD+, NMR spectroscopy

Motivation: The rising popularity of NAD+ precursors to alleviate metabolic stress in aging necessitates a close monitoring of tissue metabolic status.

Goal(s): FINUTE and 2H-MRS are used monitor lipid homeostasis and glucose metabolism in the brains of healthy mice following supplementation of nicotinamide riboside (NR), a widely used NAD+ precursor.

Approach: Mice administered saline or NR intraperitoneally for one week are imaged to assess lipid integrity. 2H-MRS is performed following administration of labeled glucose to monitor downstream metabolite labeling.

Results: Mice administered NR show increased lipid integrity and improved glucose metabolism, determined through increased labeling of Glx (TCA) and lower labeling of lactate (glycolysis).

Impact: Nicotinamide riboside has potential in improving cerebral glucose metabolism and lipid integrity as assessed by lipid-sensitive MRI and 2H-MR spectroscopy, necessitating further exploration of NR and other NAD+ precursors both clinically and in aging-related diseases using these methods.

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Keywords