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Abstract #2918

Deuterium metabolic imaging in epilepsy patients at 7T

Narjes Ahmadian1, Romy Buijs2, Maaike Konig2, Mark Gosselink2, Pieter van Eijsden2, Sigrid Otto2, Kiki Tesselaar2, Jeanine Prompers2, Dennis Klomp2, and Evita Wiegers2
1Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, 2University Medical Center Utrecht, Utrecht, Netherlands

Synopsis

Keywords: Spectroscopy, Epilepsy

Motivation: Identifying the epileptogenic zone (EZ) in MRI-negative epilepsy patients is crucial for surgical success.

Goal(s): To investigate whether dynamic deuterium metabolic imaging (DMI) can detect subtle metabolic disturbances in MRI-negative epilepsy patients.

Approach: Five patients consumed [6,6'-2H2]glucose, and underwent dynamic DMI at 7 Tesla to track 2H-Glc (glucose) and 2H-Glx (glutamate/glutamine) levels in the epileptogenic zone (EZ) and non-epileptogenic contralateral region.

Results: Both 2H-Glc and 2H-Glx levels increased over time, but no significant metabolic differences were observed between EZ and the contralateral region in the interictal phase.

Impact: Dynamic DMI offers a non-invasive approach to assess epilepsy metabolism. Although this study observed no metabolic differences between the epileptogenic-zone and contralateral normal-appearing brain tissue interictally, DMI should be considered for direct post-ictal imaging, potentially aiding diagnosis in MRI-negative epilepsy.

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Keywords