Abstract #2925

Probing tumor microenvironment with time-dependent diffusion MRS and machine learning based modeling in C6 Glioma

Ke Zhou¹, Ziyan Wang², Yang Cao³, Xinyi Zhu¹, Yufan Zhou¹, Yibo Liu⁴, Chunli Cai⁵, Yi-Cheng Hsu⁶, Sheng Chen⁴, and Min Wang^1,7

¹Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ²Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ³Beijing Wandong Medical Technology Co.,Ltd., Beijing, China, ⁴Department of Neurosurgery, School of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China, ⁵Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, China, ⁶MR Collaboration, Siemens Healthcare Ltd, Shanghai, China, ⁷School of Medicine, Sir Run Run Shaw Hospital, Department of Endocrinology, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Spectroscopy, Microstructure

Motivation: Diffusion-weighted MR Spectroscopy(DW-MRS) enables access to diffusion properties of intracellular metabolites to characterize brain cell-specific microstructure, potentially reflecting cellular changes in tumor microenvironment(TME).

Goal(s): To measure time-dependent diffusion kurtosis of intracellular metabolites and to compute biophysical model of cellular changes in TME.

Approach: In-vivo DW-MRS and machine learning(ML)-based model were applied to measure tumor microstructural changes with different diffusion-times(Td) in 11 normal and 11 C6-glioma rat models.

Results: Changes in neuronal(tNAA) and glial(tCho) metabolites' time-dependent diffusion indicate neuronal atrophy and glial activation within tumor core. Microstructural and metabolic alterations, including specific cell size changes during tumor growth, suggest increased invasiveness in malignant tumors.

Impact: This work provides a unique insight into the Td-dependency of intracellular metabolites and water to probe the microstructural changes during the pathological tumor progression, which helps revealing spatial structural and metabolite profile to address the complexity of the TME.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.