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Abstract #2927

Mapping brain regional differences in young rats with chronic liver disease using fast 1H-FID-MRSI at 9.4T

Gianna Nossa1,2, Brayan Alves1,2, Thanh Phong Lê1,2, Dario Sessa3, Stefanita Mitrea1,2, Jessie Mosso1,2, Bernard Lanz1,2, Valerie McLin3, and Cristina Cudalbu1,2
1CIBM Center fro Biomedical Imaging, Lausanne, Switzerland, 2Animal Imaging and Technology, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, 3Swiss Pediatric Liver Center, Pediatric Gastroenterology, Hepatology and Nutrition Unit, Department of Pediatrics, Gynecology and Obstetrics, University of Geneva, Geneva, Switzerland

Synopsis

Keywords: Spectroscopy, Brain

Motivation: Type C hepatic encephalopathy (HE) is increasingly suspected in children with chronic liver disease (CLD) and various brain regions might be affected.

Goal(s): To investigate the potential of 1H-FID-MRSI to detect metabolic and brain regional changes in a model of CLD during brain development and maturation.

Approach: Bile duct ligated and sham rats operated at p21 days after birth underwent 1H-FID-MRSI 6-weeks post-ligation at 9.4T.

Results: Using 1H-FID-MRSI, we detected and mapped the metabolic changes in the developing brain with CLD, investigated brain regional changes, and proved the potential of 1H-FID-MRSI to detect small changes due to individual animal response to disease.

Impact: Our study demonstrated the potential of 1H-FID-MRSI at 9.4T to detect and map metabolic changes in the developing brain in a rat model of chronic liver disease, specifically regional differences and changes in Gln due to individual response to disease.

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Keywords