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Abstract #2930

Retrospective lipid removal in preclinical 1H-FID MRSI at ultra-high field and potential effects on metabolite concentration estimates

Tan Toi Phan1,2, Brayan Alves1,2, Thanh Phong Lê1,2, Antoine Klauser3, Bernard Lanz1,2, and Cristina Cudalbu1,2
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 2Animal Imaging and Technology, École polytechnique fédérale de Lausanne, Lausanne, Switzerland, 3Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland

Synopsis

Keywords: Spectroscopy, Brain, Lipid, MRSI, rat, spectroscopic imaging

Motivation: Robust and efficient solutions are needed to accurately remove lipid signals for fast 1H-MRSI in the rodent brain while preserving the metabolite signals.

Goal(s): Analyze the effects of retrospective lipid suppression on metabolite estimates at 14.1T in the rat brain for 1H-FID-MRSI.

Approach: SVD-based lipid suppression was applied for retrospective lipid suppression.

Results: Overall, the retrospective lipid suppression is slightly influencing the metabolite concentration estimates in the rat brain for 1H-FID-MRSI at 14.1T.

Impact: Our work is evaluating the retrospective lipid suppression on metabolite estimates at 14.1T in the rat brain for 1H-FID-MRSI. When using low lipid contaminated data, an effect on concentration estimates was observed, highlighting the need for future investigations.

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